Innate immunity provides the body’s rapid first line of defence against pathogens, damaged cells and other biological threats. Research into innate immune signalling is important for understanding infectious disease, inflammation, autoimmune disorders, cancer and inflammatory forms of cell death.
ABclonal has assembled a curated collection of validated antibodies for studying important components of the innate immune response. The featured targets include STING/TMEM173, IRF3, NF-κB p65/RelA, NLRP3, cleaved Gasdermin E and JAK2. Together, these targets cover several widely studied pathways involved in pathogen recognition, interferon responses, inflammasome activation, inflammatory signalling and cytokine regulation.
Reliable antibody specificity is particularly important when examining signalling pathways in which phosphorylation, protein cleavage, nuclear translocation or relatively small changes in expression may indicate pathway activation. Several antibodies in this collection have been validated using knockout samples, providing additional evidence that the detected signal corresponds to the intended target.
Key Innate Immunity Research Targets
These antibodies support research across interconnected innate immune pathways. STING and IRF3 are central to cytosolic DNA sensing and type I interferon responses. NF-κB p65 is a major transcriptional regulator of inflammatory genes, while NLRP3 is a core component of one of the most extensively studied inflammasomes. Cleaved Gasdermin E is associated with pore formation and inflammatory cell death, and JAK2 participates in cytokine receptor signalling through the JAK–STAT pathway.
STING/TMEM173 Rabbit mAb
Catalogue number: A21051
STING is an important mediator of cytosolic DNA sensing and type I interferon signalling. It is widely studied in antiviral immunity, inflammation, cancer immunology and the cellular response to abnormal DNA.
KO Validated IRF3 Rabbit mAb
Catalogue number: A27272
IRF3 is a transcription factor activated downstream of several innate immune sensors. It regulates type I interferon production and is commonly investigated in antiviral and nucleic-acid sensing pathways.
KO Validated NF-κB p65/RelA Rabbit mAb
Catalogue number: A19653
NF-κB p65, also known as RelA, regulates genes involved in inflammation, immune-cell activation, survival and stress responses. Its activation and nuclear translocation are frequently measured in innate immunity research.
NLRP3 Rabbit mAb
Catalogue number: A24294
NLRP3 is a sensor protein involved in assembly of the NLRP3 inflammasome. It is studied extensively in infection, metabolic inflammation, neuroinflammation and other inflammatory diseases.
KO Validated Cleaved Gasdermin E Rabbit mAb
Catalogue number: A26197
Cleavage of Gasdermin E releases its pore-forming N-terminal fragment. Detection of this fragment can assist studies of inflammatory cell death, membrane permeabilisation and links between apoptotic and pyroptotic pathways.
KO Validated JAK2 Rabbit mAb
Catalogue number: A28566
JAK2 is a tyrosine kinase that transmits signals from multiple cytokine and growth-factor receptors. It is an important target in studies of immune regulation, inflammation, haematopoiesis and JAK–STAT signalling.
Antibody Validation for Reliable Innate Immunity Research
Antibody validation helps researchers distinguish specific target detection from non-specific background. Knockout validation is especially useful because the disappearance of the expected signal in a target-deficient sample provides strong evidence of antibody specificity. Researchers should still confirm that each antibody is suitable for their sample type, species and intended application.
The featured antibodies may support techniques such as western blotting, immunohistochemistry, immunofluorescence and immunoprecipitation, depending on the validation information provided for each product. Follow the individual product links above to review recommended applications, species reactivity, dilution guidance and supporting validation data.
ABclonal Products Available from Genesearch
Genesearch is the authorised Australian distributor for ABclonal. Australian researchers can order ABclonal antibodies, ELISA kits, recombinant proteins, molecular enzymes and other laboratory reagents through Genesearch in Australian dollars.
Use the Genesearch online catalogue to search products and view Australian pricing. For assistance identifying a suitable antibody, use the telephone, email or live chat contact options displayed at the top or bottom of this page.
